According to Beatrice Golomb, MD, PhD as the University of California, this standard has a fundamental problem. She explains by adding, there isn’t anything actually known to be physiologically inert.  There are also no regulations as to what a placebo is made of.  What is in a placebo is often determined by the makers of the drug being studied.  These makers have a vested interest in the outcome of the test.

Nobody knows how often the results of a study are affected by the ingredient of the placebo. This leaves doctors wondering how a standard can be be created when less then ten percent of cases disclose what is in the placebo. Golomb added that a good or bad effect of the placebo can be misleading of a positive or negative effect of the drug.

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